Tetrahedron Letters

Synthesis of substituted 1-benzazepin-2-ones via ring-closing olefin metathesis

SB Hoyt, C London, M Park

文献索引：Hoyt, Scott B.; London, Clare; Park, Min Tetrahedron Letters, 2009 , vol. 50, # 17 p. 1911 - 1913

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被引用次数: 15

摘要

The 1-benzazepin-2-one ring system is an important structural feature of marketed drugs, clinical candidates, and other bioactive molecules. We have developed a new benzazepinone synthesis that employs ring-closing olefin metathesis as a key step. This route provides efficient access to substituted benzazepinones that are difficult to synthesize via existing procedures.