Inhibitors of type III secretion in Yersinia: design, synthesis and multivariate QSAR of 2-arylsulfonylamino-benzanilides
…, HA Norberg, C Sundin, A Linusson, M Elofsson
文献索引：Kauppi, Anna M.; Andersson, C. David; Norberg, Henrik A.; Sundin, Charlotta; Linusson, Anna; Elofsson, Mikael Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 22 p. 6994 - 7011
Compound 1, 2-(benzo [1, 2, 5] thiadiazole-4-sulfonylamino)-5-chloro-N-(3, 4-dichloro- phenyl)-benzamide, was identified as a putative type III secretion inhibitor in Yersinia, and the compound thus has a potential to be used to prevent or treat bacterial infections. A set of seven analogues was synthesized and evaluated in a type III secretion dependent reporter- gene assay with viable bacterial to give basic SAR. A second set of 19 compounds was ...
