Although the synthesis of tert-butyl ethers by acidcatalyzed reaction of an alcohol and a tert- butyl cation source is one of the classical methods of organic chemistry, the corresponding tert-alkylation reaction of primary or secondary amines has not proven generally useful. Acids strong enough to generate tert-butyl cations from isobutylene first protonate the more basic amine, rendering it non-nucleophilic. Previously reported conditions suffer from low ...
