Il Farmaco

Design and development of 2, 3-benzodiazepine (CFM) noncompetitive AMPA receptor antagonists

R Gitto, M Zappalà, G De Sarro, A Chimirri

文献索引：Gitto, Rosaria; Zappala, Maria; De Sarro, Giovambattista; Chimirri, Alba Farmaco, 2002 , vol. 57, # 2 p. 129 - 134

全文：HTML全文

被引用次数: 27

摘要

2, 3-Benzodiazepines represent a class of heterocyclic compounds that interact with AMPA- type glutamate receptors in a noncompetitive manner. These compounds have attracted great interest for their pharmacological effects against acute and chronic neurodegenerative diseases, such as ischemia and epilepsy. We synthesized a large number of 2, 3- benzodiazepine derivatives, which showed anticonvulsant properties in different seizure ...