Methyl 6-C-alkyl-6-deoxy-α-d-mannofuranoside derivatives have been synthesized from methyl 2, 3-O-isopropylidene-5, 6-O-sulfuryl-α-d-mannofuranoside (1). In a Path A, reaction of the 5, 6-cyclic sulfate 1 with 2-lithio-1, 3-dithiane afforded 2-(methyl 6-deoxy-2, 3-O- isopropylidene-α-d-mannofuranosid-6-yl)-1, 3-dithiane (2). Treatment of 2 with n-butyllithium then alkyl iodide gave the corresponding 2-(methyl 5-O-alkyl-6-deoxy-2, 3-O- ...
