Antibody-catalyzed rearrangement of a peptide bond: mechanistic and kinetic investigations

…, SD Taylor, PA Benkovic, SJ Benkovic

文献索引：Liotta; Gibbs; Taylor; Benkovic Journal of the American Chemical Society, 1995 , vol. 117, # 17 p. 4729 - 4741

全文：HTML全文

被引用次数: 17

摘要

Abstract: Catalysis of the deamidation of asparagine residues may provide a powerful method for the deactivation of proteins. Catalytic antibodies (Gibbs et al. Science 1992, 258,803) have been induced that catalyze the deamidation of a model dipeptide through an intermediate succinimide. Investigations of the mechanistic characteristics of two such antibodies, RG2-23C7 and RG2-2E4, revealed their ability to accelerate the hydrolysis of ...