Novel styrylpyridines as probes for SPECT imaging of amyloid plaques

W Qu, MP Kung, C Hou, TE Benedum…

文献索引：Qu, Wenchao; Kung, Mei-Ping; Hou, Catherine; Benedum, Tyler E.; Kung, Hank F. Journal of Medicinal Chemistry, 2007 , vol. 50, # 9 p. 2157 - 2165

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被引用次数: 53

摘要

We report a series of radioiodinated styrylpyridines as single photon emission computed tomography probes for imaging Aβ plaques in the brain of patients with Alzheimer's disease (AD). In vitro binding showed that all of the styrylpyridines displayed very good binding affinities in postmortem AD brain homogenates (K i= 3.6 to 15.5 nM). No-carrier-added samples of 13a, 13b, 16a, 16b, and 16e (radioiodinated with 125I) were successfully ...