Synthesis

Regioselective synthesis of 1, 3, 5-substituted pyrazoles from acetylenic ketones and hydrazines

BC Bishop, KMJ Brands, AD Gibb, DJ Kennedy

文献索引：Bishop, Brian C.; Brands, Karel M. J.; Gibb, Andrew D.; Kennedy, Derek J. Synthesis, 2004 , # 1 p. 43 - 52

被引用次数: 91

摘要

Abstract The synthesis of diversely substituted 1, 3, 5-substituted pyrazoles from the reaction of acetylenic ketones with substituted hydrazines is reported. The reactions were shown to be highly regioselective regardless of the nature of the substituents in the substrates and afforded essentially single pyrazole isomers in excellent yields.

20442-65-3

3-苯基-1-对甲苯丙酮

~82%

~83%

~84%

~0%

~0%

~80%

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