Condensation reactions. II. Alkylidene cyanoacetic and malonic esters

AC Cope, CM Hofmann, C Wyckoff…

文献索引：Cope et al. Journal of the American Chemical Society, 1941 , vol. 63, p. 3455

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被引用次数: 179

摘要

A method for condensing aliphatic ketones with cyanoacetic ester was reported recently,'in which the reactants were heated in the presence of acetamide and acetic acid, the water formed in the condensation being removed continuously by slow distillation of the acetic acid. The method is not convenient for condensing ethyl cyanoacetate with low boiling ketones, which are removed during the distillation and must be used in large excess, or for ...