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Journal of medicinal chemistry

Antiulcer agents. p-aminobenzamido aromatic compounds

RB Moffett, A Rober, LL Skaletzky

文献索引:Moffett,R.B. et al. Journal of Medicinal Chemistry, 1971 , vol. 14, p. 963 - 968

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被引用次数: 26

摘要

Gastrointestinal ulcers are commonly treated by diet, antacids, anticholinergics, or surgery. Anticholinergics reduce the amount of gastric juice and its acidity and also the motility of the stomach and intestine. Although nidely used, they are by no means the final answer. Gastric ulcers can be produced in rats by restraint, forced exertion, pylorus ligation, or by administration of certain adrenal cortical hormones. Anticholinergics are active in ...