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One-Pot Synthesis of new imidazo [1, 2-a] pyridine and imidazo [1, 2-a] pyrimidine derivatives

F Georgescu, E Georgescu, C Draghici…

文献索引:Georgescu, Florentina; Georgescu, Emilian; Draghici, Constantin; Iuhas, Paula C.; Filip, Petru I. Revue Roumaine de Chimie, 2005 , vol. 50, # 5 p. 349 - 352

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被引用次数: 5

摘要

Résumé/Abstract New imidazo [1, 2-a] pyridine and imidazo [1, 2-a] pyrimidine derivatives were easily obtained by an one-pot synthesis that implies the reaction of the corresponding 2-aminoheterocycles with N, N-dimethylfomiamide dimethylacetal (DMFDMA), followed by the reaction of intermediate N-heteroarylformamidine (without isolation) with reactive α- halocarbonyl compounds. In this way, new 3-substituted imidazol 1, 2-a] pyridine and ...