Synthesis of dicationic diaryltriazines nucleic acid binding agents

J Spychala, DW Boykin, WD Wilson, M Zhao…

文献索引：Spychala; Boykin; Wilson; Zhao; Tidwell; Dykstra; Hall; Jones; Schinazi European Journal of Medicinal Chemistry, 1994 , vol. 29, # 5 p. 363 - 367

全文：HTML全文

被引用次数: 25

摘要

Abstract The synthesis of 2, 4-bis [4-(4, 5-dihydro-1H-imidazol-2-yl) phenyl]-1, 3, 5-triazine 6a and 2, 4-bis [4-(1, 4, 5, 6-tetrahydropyrimidin-2-yl) phenyl]-1, 3, 5-triazine 6b in 3 steps from either 4-bromobenzamidine or 4-(carbamoyl) benzamidine is reported. The synthesis of 4, 6-bis [4-(4, 5-dihydro-1H-imidazol-2-yl) phenyl]-2-dimethylamino-1, 3, 5-triazine 9a and 4, 6-bis [4-(1, 4, 5, 6-tetrahydropyrimidin-2-yl) phenyl]-2-dimethylamino-1, 3, 5-triazine 9b in ...