Angewandte Chemie International Edition

Iridium??Catalyzed Intermolecular Allylic Etherification with Aliphatic Alkoxides: Asymmetric Synthesis of Dihydropyrans and Dihydrofurans

C Shu, JF Hartwig

文献索引：Shu, Chutian; Hartwig, John F. Angewandte Chemie - International Edition, 2004 , vol. 43, # 36 p. 4794 - 4797

全文：HTML全文

被引用次数: 152

摘要

Entry R1 (1) R2 (2) 3/4 [b] Yield [%][c] ee [%][d] 1 [e] Me (1b) Bn (2d) 95: 5 80 97 2 Ph (1a) iPr2CH (2e) 99: 1 86 96 3 1a 1-cyclohexyl (2 f) 97: 3 79 94 4 1a N-Boc-4-piperidinyl (2g) 98: 2 70 [f] 95 5 1b 2g 97: 3 56 [f] 94 6 nPr (1c) 2g 92: 8 66 [f] 93 7 [g] p-NO2C6H4 (1d) 2 f 94: 6 59 86 8 [g] p-MeOC6H4 (1e) 2 f 99: 1 86 95 9 [h] 1a tBu (2h) 96: 4 80 63 10 1a(S)-1-(2-Np)-1- ethyl (2i) 99: 1 90 95 de 11 [i] 1a 2i 99: 1 91 [j] 93 de 12 E-CH3CH= CH (1 f) 2i 98: 2 90 96 ...