Chemistry Letters

Synthesis of Z-1, 1-Dichloro-2-(4-(2-dimethylaminoethoxy) phenyl)-2-(4-hydroxyphenyl)-3-phenyl Cyclopropane and Z-1, 1-Dichloro-2-(4-(2-dimethylaminoethoxy) …

S Singh, RA Magarian

文献索引：Singh, Satendra; Magarian, Robert A. Chemistry Letters, 1994 , # 10 p. 1821 - 1824

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摘要

The synthesis of title compounds is described. The key steps in the synthesis are the preparation of the pure Z-ethene, the stereospecific addition of dichlorocarbene, amino- dehalogenation and deprotection of the phenol. Heptafluorotolyl protecting group is used in the synthesis of pure Z-ethene which is stable under basic heterogenous cyclopropanation reaction conditions.