A flavoprotein monooxygenase that catalyses a Baeyer–Villiger reaction and thioether oxidation using NADH as the nicotinamide cofactor

…, J Cartwright, J Ward, S Hart, JP Turkenburg…

文献索引：Jensen, Chantel N.; Cartwright, Jared; Ward, Jonathan; Hart, Sam; Turkenburg, Johan P.; Ali, Sohail T.; Allen, Michael J.; Grogan, Gideon ChemBioChem, 2012 , vol. 13, # 6 p. 872 - 878

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被引用次数: 26

摘要

Abstract A gene from the marine bacterium Stenotrophomonas maltophilia encodes a 38.6 kDa FAD-containing flavoprotein (Uniprot B2FLR2) named S. maltophilia flavin-containing monooxygenase (SMFMO), which catalyses the oxidation of thioethers and also the regioselective Baeyer–Villiger oxidation of the model substrate bicyclo [3.2. 0] hept-2-en-6- one. The enzyme was unusual in its ability to employ either NADH or NADPH as ...