Organic letters

Total synthesis of (±)-trachyspic acid and determination of the relative configuration

…, H Ooi, T Esumi, Y Iwabuchi, S Hatakeyama

文献索引：Hirai, Kanako; Ooi, Hidenori; Esumi, Tomoyuki; Iwabuchi, Yoshiharu; Hatakeyama, Susumi Organic Letters, 2003 , vol. 5, # 6 p. 857 - 859

全文：HTML全文

被引用次数: 34

摘要

The first total synthesis of (±)-trachyspic acid, a tumor cell heparanase inhibitor, was accomplished based on Cr (II)/Ni (II)-mediated reaction of the aldehyde containing the citric acid moiety and the long-chain triflate, and the relative configuration of this natural product was determined.