Acta Poloniae Pharmaceutica-Drug Research

Synthesis and anticonvulsant activity of substituted oxadiazole and thiadiazole derivatives

MS Yar, MW Akhter

文献索引：Yar, Mohammad Shahar; Akhter, Mohammad Wasim Acta Poloniae Pharmaceutica - Drug Research, 2009 , vol. 66, # 4 p. 393 - 397

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被引用次数: 55

摘要

Abstract: A series of five membered heterocyclics was synthesized by the reaction between isoniazid and various substituted isothiocyanates and was tested for their anticonvulsant activity by determining their ability to provide protection against convulsions induced by electroconvulsometer. Among the synthesized compounds,(IIf) 2-(4-chlorophenyl) amino-5- (4-pyridyl)-1, 3, 4-thiadiazole and (IIIf) 2-(4-chlorophenyl) amino-5-(4-pyridyl)-1, 3, 4- ...