m-(N, N, N-Trimethylammonio) trifluoroacetophenone: A femtomolar inhibitor of acetylcholinesterase

HK Nair, K Lee, DM Quinn

文献索引：Nair, Haridasan K.; Lee, Keun; Quinn, Daniel M. Journal of the American Chemical Society, 1993 , vol. 115, # 22 p. 9939 - 9941

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被引用次数: 61

摘要

Abstract: m-(N, N, N-Trimethy1ammonio) trifluoroacetophenone is a potent, reversible, time- dependent inhibitor of acetylcholinesterases. The respective second-order rate constants (k,) for binding of the ketone to enzymes from Electrophorus electricus and Torpedo calijornica are (1.2 f 0.2) X lo5 and (1.0+ 0.2) X lo5 M-1 sl, while the corresponding dissociation rate constants (k, ff) are (1. O f 0.2) X and (1. O f 0.3) X 10-4 sI. Therefore, the ...