1H-1, 3-Benzazaphospholes: The organometallic route and a new three-step synthesis with reductive ring closure

…, N Gupta, J Heinicke, GN Nikonov, F Saguitova…

文献索引：Bansal, Raj K.; Gupta, Neelima; Heinicke, Joachim; Nikonov, George N.; Saguitova, Farida; Sharma, Dinesh C. Synthesis, 1999 , # 2 p. 264 - 269

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被引用次数: 19

摘要

Abstract: Primary and N-secondary 2-phosphanylanilines were synthesized via metallation of 2-bromoanilines, coupling with ClP (NMe2) 2, alcoholysis and reduction with LiAlH4, and subsequently reacted with formimidoester hydrochloride to give 1, 3-benzazaphospholes. For 1H-1, 3-benzazaphospholes, a shorter alternative three-step synthesis was developed, based on N-acylation of 2-bromoaniline, NiCl2-catalyzed arylation of triethyl phosphite ...