Syntheses of lipophilic chalcones and their conformationally restricted analogues as antitubercular agents

…, JP Thakur, D Chanda, D Saikia, F Khan, S Dixit…

文献索引：Ahmad, Imran; Thakur, Jay Prakash; Chanda, Debabrata; Saikia, Dharmendra; Khan, Feroz; Dixit, Shivani; Kumar, Amit; Konwar, Rituraj; Negi, Arvind Singh; Gupta, Atul Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1322 - 1325

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被引用次数: 14

摘要

Lipophilic chalcones and their conformationally restricted analogues were synthesized and evaluated for their antitubercular efficacy against Mycobacterium tuberculosis H37Rv strain. Compounds 16, 24, 25a and 25c were found to be active MIC at 60, 30, 3.5 and 7.5 μg-mL− 1. In vitro cytotoxicity of compounds 16, 24, 25a, 25c and 26 in non-cancerous human epithelial kidney cell line (HEK-293) showed that most active compound 25a was ...