Abstract A series of basic esters of 3, 4, 5-trimethoxybenzoic acid has been synthesized and the compounds evaluated for antihypertensive and local anesthetic activity. One of the compounds, a diamine ester prepared from N-methyl-N-phenyl-N′-propyl-ethylenediamine via a three-step synthesis, exhibited hypotensive activity following intravenous administration to normotensive dogs. No hypotensive activity was demonstrated following ...
