Benzylic Ligand Hydroxylation Starting from a Dicopper μ?螃?2: η2 Peroxo Intermediate: Dramatic Acceleration of the Reaction by Hydrogen??Atom Donors

M Rolff, JN Hamann, F Tuczek

文献索引：Rolff, Malte; Hamann, Jessica Nadine; Tuczek, Felix Angewandte Chemie - International Edition, 2011 , vol. 50, # 30 p. 6924 - 6927

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被引用次数: 10

摘要

The ubiquitous copper enzyme tyrosinase catalyzes the ohydroxylation of monophenols to catechols along with subsequent two-electron oxidation to o-quinones.[1–3] Its physiological function is to initiate melanin synthesis by converting tyrosine to dopaquinone, which spontaneously polymerizes in a non-enzymatic reaction cascade.[4, 5] Various recent crystal structures of different tyrosinases revealed a binuclear copper type 3 active site, with each ...