Alkyl hydroxybenzoic acid derivatives that inhibit HIV-1 protease dimerization
…, VS Bolzani, M Reboud-Ravaux
文献索引：Flausino Jr., O. A.; Dufau, L.; Reboud-Ravaux, M.; Regasini, L. O.; Petronio, M. S.; Silva, D. H. S.; Bolzani, V. S.; Rose, T. Current Medicinal Chemistry, 2012 , vol. 19, # 26 p. 4534 - 4540,7
The therapeutic potential of gallic acid and its derivatives as anti-cancer, antimicrobial and antiviral agents is well known. We have examined the mechanism by which natural gallic acid and newly synthesized gallic acid alkyl esters and related protocatechuic acid alkyl esters inhibit HIV-1 protease to compare the influence of the aromatic ring substitutions on inhibition. We used Zhang-Poorman's kinetic analysis and fluorescent probe binding to ...
