Synthesis, NMR and MS study of novel N-sulfonylated purine derivatives

B Žinić, I Krizmanić, D Vikić-Topić, D Srzić…

文献索引：Zinic, Biserka; Krizmanic, Irena; Vikic-Topic, Drazen; Srzic, Dunja; Zinic, Mladen Croatica Chemica Acta, 2001 , vol. 74, # 2 p. 399 - 414

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被引用次数: 3

摘要

Sažetak Tosylation and mesylation of adenine (1) at room temperature give regioselectively N 9-sulfonylated purines 2 and 5. Excess of TsCl or MsCl at higher reaction temperatures leads to formation of unstable N 6, N 9-disulfonylated products 3 and 6, which easily transform into the corresponding N 9-monosulfonylated product 4. Two N-sulfonylated purine nucleoside derivatives 12 and 15 have also been prepared. 1D/2D NMR ...