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Synlett

Application of piperazine-derived hydrazone linkers for alkylation of solid-phase immobilized ketones

R Lazny, M Michalak

文献索引:Lazny, Ryszard; Michalak, Michal Synlett, 2002 , # 11 p. 1931 - 1934

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被引用次数: 6

摘要

Abstract The preparation and application of three new solid supports with piperazine- derived hydrazine anchoring groups are described. The supports were used for immobilization of ketones. The ketones: cyclohexanone, 4-tert-butylcyclohexanone, 3- pentanone and tropinone, which were bound to polymers in the form of their hydrazones, were deprotonated with LDA and alkylated with propyl iodide or benzyl bromide. The ...