Mechanism of induction of Parkinson's disease by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Chemical and electrochemical characterization of a geminal …
…, PK Arora, SC Feke, FL Urbach
文献索引：Sayre; Arora; Feke; Urbach Journal of the American Chemical Society, 1986 , vol. 108, # 9 p. 2464 - 2466
The discovery that 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP, l), present as an impurity in an illicit narcotic preparation, produced an irreversible Parkinson's Disease (PD) syndrome in man1 has led to vigorous research aimed at elucidating the molecular mechanisms responsible for this effect.*" As in PD, MPTP neurotoxicity is associated with the selective destruction of the substantia nigra, a pigmented (neuromelanin) dopaminergic ...
