Selective. beta. 3-adrenergic agonists of brown adipose tissue and thermogenesis. 1.[4-[2-[(2-Hydroxy-3-phenoxypropyl) amino] ethoxy] phenoxy] acetates

R Howe, BS Rao, BR Holloway…

文献索引：Howe, Ralph; Rao, Balbir S.; Holloway, Brian R.; Stribling, Donald Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1751 - 1759

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被引用次数: 40

摘要

The ester methyl [4-[2-[(2-hydroxy-3-phenoxypropyl) amino] ethoxy] phenoxy] acetate (8) has been identified as the most interesting member of a series of selective B3-adrenergic agonists of brown adipose tissue and thermogenesis in the rat In vivo it acts mainly via the related acid 10. Potency was generally markedly reduced by placing substituenta on the phenyl ring of the phenoxypropanolamine unit of 8; only the 2-fluor0 analogue 16 had ...