Development of selective and reversible pyrazoline based MAO-A inhibitors: Synthesis, biological evaluation and docking studies

M Karuppasamy, M Mahapatra, S Yabanoglu…

文献索引：Karuppasamy, Muthukumar; Mahapatra, Manojkumar; Yabanoglu, Samiye; Ucar, Gulberk; Sinha, Barij Nayan; Basu, Arijit; Mishra, Nibha; Sharon, Ashoke; Kulandaivelu, Umasankar; Jayaprakash, Venkatesan Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 5 p. 1875 - 1881

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被引用次数: 39

摘要

3, 5-Diaryl pyrazolines analogs were synthesized and evaluated for their monoamine oxidase (MAO) inhibitory activity. The compounds were found reversible and selective towards MAO-A with selectivity index in the magnitude of 103–105. The docking studies were carried out to gain further structural insights of the binding mode and possible interactions with the active site of MAO-A. Interestingly, the theoretical (Ki) values obtained ...