A noncoded amino acid of cyclomarin A (1) was synthesized in a racemic fashion. The method employs a six-membered ring template to control the relative stereochemistry and introduction of the functional groups. Ultimately, Pd-catalyzed fragmentation of the lactone provided γ, δ-unsaturated and δ, ε-unsaturated α-amino acids. A Pd-catalyzed ring opening of a γ-lactone is also reported.
