Phosphorinanes as ligands for palladium-catalyzed cross-coupling chemistry

T Brenstrum, J Clattenburg, J Britten, S Zavorine…

文献索引：Brenstrum, Tim; Clattenburg, Julie; Britten, James; Zavorine, Serguei; Dyck, Jeff; Robertson, Alan J.; McNulty, James; Capretta, Alfredo Organic Letters, 2006 , vol. 8, # 1 p. 103 - 105

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被引用次数: 36

摘要

Phosphorinanes are presented as a class of phosphine ligand suitable for organopalladium cross-coupling chemistry. Prepared via a direct double Michael addition of a monoalkyl-or arylphosphine to phorone followed by a Wolf-Kishner reduction, phosphorinanes are relatively inexpensive to manufacture and allow modification of one of the alkyl moieties permitting steric and electronic fine-tuning of the ligands. Library screening and ...