Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for …

…, JM Davis, GT Grosu, J Baker, J Ellingboe…

文献索引：Aranapakam, Venkatesan; Davis, Jamie M.; Grosu, George T.; Baker, Jannie; Ellingboe, John; Zask, Arie; Levin, Jeremy I.; Sandanayaka, Vincent P.; Du, Mila; Skotnicki, Jerauld S.; DiJoseph, John F.; Sung, Amy; Sharr, Michele A.; Killar, Loran M.; Walter, Thomas; Jin, Guixian; Cowling, Rebecca; Tillett, Jeff; Zhao, Weiguang; McDevitt, Joseph; Xu, Zhang Bao Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2376 - 2396

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被引用次数: 82

摘要

The matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases that play a key role in both physiological and pathological tissue degradation. In our preceding paper, we have reported on a series of novel and orally active N-hydroxy-α- phenylsulfonylacetamide derivatives. However, these compounds had two drawbacks (moderate selectivity and chirality issues). To circumvent these two problems, a series of ...