Synthesis, antitumour and antimicrobial activities of new peptidyl derivatives containing the 1, 3-benzodioxole system
…, IA de Souza, JM de Araújo, DJ Brondani
文献索引：Leite, Ana Cristina Lima; Peixoto Da Silva, Kezia; De Souza, Ivone A.; Magali De Araujo, Janete; Brondani, Dalci Jose European Journal of Medicinal Chemistry, 2004 , vol. 39, # 12 p. 1059 - 1065
Two series of 5 and 6-substituted 1, 3-benzodioxole peptidyl derivatives were synthesized and evaluated as antitumour and antimicrobial agents. The compounds that could be conveniently prepared in a few steps processes from natural safrole have been characterised by IR and 1H-NMR spectroscopy. In vivo antitumor activity tests showed that some of the compounds were able to inhibit carcinoma S-180 tumour growth in mice. The ...
