Tetrahedron

An efficient synthetic route to functionalized δ-lactams

A Samarat, JB Kraïem, TB Ayed, H Amri

文献索引：Samarat, Ali; Ben Kraiem, Jihene; Ben Ayed, Taicir; Amri, Hassen Tetrahedron, 2008 , vol. 64, # 40 p. 9540 - 9543

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被引用次数: 6

摘要

Six-membered nitrogen-containing heterocycles are common skeletons in many natural products and exhibit diverse and important biological properties. 1 and 2 Alkaloids that contain the piperidine ring are targets for medicinal chemistry. 3, 4, 5, 6 and 7 Accordingly, functionalized δ-lactams have been generally used as precursors of the corresponding piperidines. 8, 9 and 10 Functionalized δ-lactams and structurally related compounds have attracted considerable attention ...