Rhodium (i)-catalyzed 1, 4-conjugate arylation toward β-fluoroalkylated electron-deficient alkenes: a new entry to a construction of a tertiary carbon center possessing …
Treatment of β-fluoroalkylated-α, β-unsaturated ketones with 1.2 equiv. of various arylboronic acids in the presence of 5 mol% of [Rh (COD) 2] BF4 and 6 mol% of (S)-BINAP in toluene/H2O (v/v= 4/1) at the reflux temperature for 3 h gave the corresponding Michael adducts in high yields with over 90% enantioselectivity. Though other electron-deficient alkenes, such as vinylsulfone and vinylphosphonate, were found to be much less reactive ...
