Access to Enantiopure α??Alkyl?螃漫?hydroxy Esters through Dynamic Kinetic Resolutions Employing Purified/Overexpressed Alcohol Dehydrogenases

A Cuetos, A Rioz??Martínez, FR Bisogno…

文献索引：Cuetos, Anibal; Rioz-Martinez, Ana; Bisogno, Fabricio R.; Grischek, Barbara; Lavandera, Ivan; De Gonzalo, Gonzalo; Kroutil, Wolfgang; Gotor, Vicente Advanced Synthesis and Catalysis, 2012 , vol. 354, # 9 p. 1743 - 1749

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被引用次数: 24

摘要

Abstract α-Alkyl-β-hydroxy esters were obtained via dynamic kinetic resolution (DKR) employing purified or crude E. coli overexpressed alcohol dehydrogenases (ADHs). ADH-A from R. ruber, CPADH from C. parapsilosis and TesADH from T. ethanolicus afforded syn- (2R, 3S) derivatives with very high selectivities for sterically not impeded ketones ('small- bulky'substrates), while ADHs from S. yanoikuyae (SyADH) and Ralstonia sp.(RasADH) ...