Synthesis and activity of novel bile-acid conjugated glucocorticoid receptor antagonists

…, B Gelius, M Grynfarb, A Goos-Nilsson, J Wang…

文献索引：Richards, Steven J.; von Geldern, Thomas W.; Jacobson, Peer; Wilcox, Denise; Nguyen, Phong; Oehman, Lars; Oesterlund, Marie; Gelius, Birgitta; Grynfarb, Marlena; Goos-Nilsson, Annika; Wang, Jiahong; Fung, Steven; Kalmanovich, Masha Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 6086 - 6090

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被引用次数: 13

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of potent steroidal glucocorticoid receptor antagonists has been discovered. After conjugation to cholic acid, the compounds retained an affinity for GR in vitro and had modest in vivo efficacy. ... A series of potent steroidal glucocorticoid receptor antagonists has been ...