N, N′-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors

…, JJ Foley, HM Sarau, J Busch-Petersen

文献索引：Nie, Hong; Widdowson, Katherine L.; Palovich, Michael R.; Fu, Wei; Elliott, John D.; Bryan, Deborah L.; Burman, Miriam; Schmidt, Dulcie B.; Foley, James J.; Sarau, Henry M.; Busch-Petersen, Jakob Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5513 - 5516

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被引用次数: 18

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of N-(2-hydroxy-3-sulfonamidobenzene)-N′-arylcyanoguanidines was prepared. In general, these compounds proved to be potent antagonists of CXCR2 while the selectivity versus CXCR1 ranged from non-selective to >200-fold. ... A series of N-(2-hydroxy-3- ...