Total synthesis and biological evaluation of structural analogs of compactin and dihydromevinolin

CH Heathcock, CR Hadley, T Rosen…

文献索引：Heathcock, Clayton H.; Hadley, Cheri R.; Rosen, Terry; Theisen, Peter D.; Hecker, Scott J. Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1858 - 1873

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被引用次数: 48

摘要

The full experimental details for the total synthesis of (+)-compactin and 19 structural analogues are reported. We have evaluated three classes of analogues as inhibitors of 3- hydroxy-3-methylglutaryl-coenzyme A reductase:(1) functional and stereoisomeric analogues that possess the full carbon skeleton of compactin or dihydromevinolin,(2) functional analogues in which one carbon of the skeleton has been replaced by oxygen, ...