A safe practical synthesis of difluorophosphonoacetic acid

…, LG Sprague, DJ Pietrzyk, SH Edelmuth

文献索引：Burton, Donald J.; Sprague, Lee G.; Pietrzyk, Donald J.; Edelmuth, Steven H. Journal of Organic Chemistry, 1984 , vol. 49, # 18 p. 3437 - 3438

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被引用次数: 23

摘要

Summary: Copper (1) halide catalyzed acylation of [(di-ethoxyphosphinyl) difluoromethyl] zinc bromide with ethyl chloroformate provides a safe, easily scaled up preparation of ethyl difluoro (diethoxyphosphiny1) acetate from readily available precursors. Silyation of this ester, followed by hydrolysis, gives difluorophosphonoacetic acid.