Targeted delivery of compounds to Trypanosoma brucei using the melamine motif

C Chollet, A Baliani, PE Wong, MP Barrett…

文献索引：Chollet, Constance; Baliani, Alessandro; Wong, Pui Ee; Barrett, Michael P.; Gilbert, Ian H. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 6 p. 2512 - 2523

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被引用次数: 29

摘要

There is an urgent need for the development of new drugs for the treatment of human African trypanosomiasis. The causative organism, Trypanosoma brucei, has been shown to have some unusual plasma membrane transporters, in particular the P2 aminopurine transporter and related permeases, which have been used for the selective targeting of trypanocidal compounds to the organism. In this paper, we report the addition of melamine-based P2- ...