Zirconium??Mediated Cross??Coupling of Terminal Alkynes and Vinyl Bromides: Selective Synthesis of Cyclobutene and 1, 3??Diene Derivatives

…, F Rodriguez, L Álvarez??Rodrigo…

文献索引：Barluenga, Jose; Rodriguez, Felix; Alvarez-Rodrigo, Lucia; Fananas, Francisco J. Chemistry - A European Journal, 2004 , vol. 10, # 1 p. 101 - 108

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被引用次数: 19

摘要

Abstract A diastereoselective synthesis of 1, 3-butadiene or cyclobutene derivatives by a zirconium-mediated reaction of alkenyllithium compounds and vinyl bromides is reported. The key steps involve the generation of zirconocene–alkyne complexes from haloalkenes and subsequent coupling with alkenyl bromides. Thus, formally the process supposes the cross-coupling reaction between a terminal alkyne and an alkenyl bromide. Moreover, the ...