Macroheterocyclic compounds. XXIII. Antihypoxic and antiamnestic properties of azacrown ethers with pharmacophore groups

NG Luk'yanenko, AV Bogatskii, TA Voronina…

文献索引：Luk'yanenko, N. G.; Bogatskii, A. V.; Voronina, T. A.; Golovenko, N. Ya.; Karaseva, T. L.; et al. Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 6 p. 403 - 405 Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 6 p. 691 - 693

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摘要

7-Hydroxy-4,6-diazaheteroauxin (lla). A mixture of 5 g (0.022 mole) of Ilia, 7 g (0.ii mole) of KCN, 60 ml of water and 15 ml of ethanol was heated at 80~ for 80 h. The solution was evaporated to dryness and the residue was treated with 20 ml of concentrated hydrochlo- ric acid. After heating for 5 h, the solution was cooled and the resulting precipitate was filtered off to give 0.9 g of fla. lib was prepared analogously. The characteristics of the synthesized compounds are ...