One pot synthesis and anticancer activity of dimeric phloroglucinols

…, A Khanna, KK Bhutani, PD Mishra, IP Singh

文献索引：Chauthe, Siddheshwar K.; Bharate, Sandip B.; Periyasamy, Giridharan; Khanna, Amit; Bhutani, Kamlesh K.; Mishra, Prabhu D.; Singh, Inder P. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 6 p. 2251 - 2256

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被引用次数: 20

摘要

A series of dimeric phloroglucinol compounds were synthesized in a single step using commercially available phloroglucinol and methanesulfonic acid. Based on the reported anticancer activity of plant derived dimeric phloroglucinols, these synthesized compounds were evaluated for their in vitro anti-proliferative activities against various cancer cell lines. Several compounds demonstrated in vitro cytotoxic effects across a wide array of tumor ...