Synthesis of lipophilic 18-crown-6 diacids for the membrane transport of alkaline-earth cations

…, CA McGavin, DM Whitfield

文献索引：Fyles, Thomas M.; McGavin, Cynthia A.; Whitfield, Dennis M. Journal of Organic Chemistry, 1984 , vol. 49, p. 753 - 761

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被引用次数: 34

摘要

The synthesis of three different types of lipophilic 18-crown-6 diacids is described. A didecyl crown ether 2, 3-diacid (1) was prepared as a minor product from a diiodide precursor (12) and threo-11, 12-docosanediol by thallous ethoxide cyclization. The major nonpolymeric products resulted from elimination followed by cyclization to give 15-crown-5 derivatives. A crown ether 11, 12-diamide 2, 3-diacid (4) was prepared by a similar route involving ...