Tetrahedron

A site selective functionalisation of 1, 3-bis (trifluoromethyl) benzene

W Dmowski, K Piasecka-Maciejewska

文献索引：Dmowski, Wojciech; Piasecka-Maciejewska, Krystyna Tetrahedron, 1998 , vol. 54, # 24 p. 6781 - 6792

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被引用次数: 7

摘要

1, 3-Bis (trifluoromethyl) benzene was regioselectively metalated and subsequently carboxylated at position 2 to give 2, 6-bis (trifluoromethyl) benzoic acid. Treatment of the acid with sulphur tetrafluoride gave 2, 6-bis (trifluoromethyl) benzoyl fluoride which was readily converted to 2, 6-bis (trifluoromethyl) benzyl alcohol and further to 2, 6-bis (trifluoromethyl) benzaldehyde. Bromination of 2, 6-bis (trifluoromethyl) benzoic acid with ...