The Journal of Organic Chemistry

The synthesis of novel antitumor antibiotics structurally related to the anthracyclinones

PN Confalone, G Pizzolato

文献索引：Confalone, Pat N.; Pizzolato, Giacomo Journal of Organic Chemistry, 1990 , vol. 55, # 20 p. 5520 - 5525

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被引用次数: 9

摘要

A practical synthesis of C (10)-functionalized derivatives of the anthracycline class of antitumor antibiotics is described. An efficient preparation of the tetracyclic epoxide 13 from the diquinone 8 and butadiene 9 yields a key intermediate for the stereospecific synthesis of