Enantioselective conjugate addition of a lithium ester enolate catalyzed by chiral lithium amides

…, A Harrison-Marchand, J Maddaluno, K Tomioka

文献索引：Duguet, Nicolas; Harrison-Marchand, Anne; Maddaluno, Jacques; Tomioka, Kiyoshi Organic Letters, 2006 , vol. 8, # 25 p. 5745 - 5748

全文：HTML全文

被引用次数: 31

摘要

Mixed aggregates of chiral lithium amide and lithium ester enolate have been employed in the enantioselective conjugate addition on α, β-unsaturated esters. Michael adducts were obtained in ee's up to 76% combining a lithium enolate and a chiral 3-aminopyrrolidine lithium amide. The sense of the induction was found to be determined by both the relative configuration of the stereogenic centers borne by the amide and the solvent in which the ...