Catalyzation of cocaine N??demethylation by cytochromes P4502B, P4503A, and P4502D in fish liver

E Arinç, A Bozcaarmutlu

文献索引：Arinc, Emel; Bozcaarmutlu, Azra Journal of Biochemical and Molecular Toxicology, 2003 , vol. 17, # 3 p. 169 - 176

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被引用次数: 16

摘要

Abstract Cocaine N-demethylation by microsomal cytochrome P450s is the principal pathway in cocaine bioactivation and hepatotoxicity. P450 isozymes involved in N- demethylation of cocaine have not been elucidated yet and they differ from species to species. In humans and mice, P4503A contributes to cocaine N-demethylase activity, whereas in rats, both P4503A and P4502B participate. In the present study, contribution of ...