Practical, cobalt-mediated, diastereoselective synthesis of the 11-(trimethylsilyl)-3-methoxyestra-1, 3, 5 (10), 8 (14), 9 (11)-pentaene nucleus: a novel steroid …

JC Clinet, E Dunach, KPC Vollhardt

文献索引：Clinet,J.C.; Dunach,E.; Vollhardt,K.P. Journal of the American Chemical Society, 1983 , vol. 105, p. 6710

全文：HTML全文

被引用次数: 33

摘要

We have recently introduced cobalt-mediated intramolecular achiral enediyne [2+ 2+ 21 cycloadditions as a synthetic method in chiral polycyclic diene construction.'We have now found that chiral substrates A (Scheme I) may in some cases [eg, R,= Si (CH3),, R,= CH3, C6H5CH2, or CH30CH2] undergo the same reaction with remarkable diastereoselectivity, out of the four possible products basically only B (major) and C (minor) being formede2 (1) ...