Theoretical consideration of the pathway of phenylalanine and tyrosine metabolism in inborn or ascorbic acid deficiency induced alcaptonuria has frequently included 2, 5- dihydroxyphenylalanine as an intermediate. Hi+ ail reported its synthesis in 1927 but the yield which he obtained was poor and it now appears that the identity of his product may be subject to question. Recently Neuberger2 reported the synthesis of this amino acid by ...
